Background: Osteopontin has been implicated in vascular calcification formation and vein graft intimal hyperplasia, and its expression can be triggered by pro-inflammatory activation of cells.The role of osteopontin and the temporal formation of microcalcification in vein grafts is poorly understood with a lack of understanding of the interaction l
Abstract Background Demyelinating diseases cause destruction of the myelin sheath, while axons are relatively spared.Pathologically, demyelination can be the result of an inflammatory process, viral infection, acquired metabolic derangement and ischemic insult.Three diseases that can cause inflammatory demyelination of the CNS are: Multiple scleros
Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the leading causes of morbidity and mortality of CTD.Clinically, CTD-ILD is highly heterogenous and involves rheumatic immunity and multiple manifestations of respiratory complications affecting the airways, vessels, lung parenchyma, pleura, and respiratory muscle
This paper addressed the heterogeneous fixed fleet open vehicle routing problem (HFFOVRP), in which the vehicles are not required to return to the depot after completing a service.In this new problem, the demands of customers are fulfilled by a heterogeneous fixed fleet of vehicles having abc material various capacities, fixed costs and variable co
We investigated the sleep onset transition in humans from an effective connectivity perspective in a baseline condition (approx.16 h of wakefulness) and after sleep deprivation (40 h of sustained wakefulness).Using EEG recordings (27 derivations), source localization (LORETA) allowed us to reconstruct the underlying patterns of neuronal activity in